Description
Like other cephalosporins, cefixime exhibits its bactericidal action by binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis.
Cefixime is indicated in the treatment of the following infections when caused by susceptible strains of the designated microorganisms: – Uncomplicated urinary tract infections – Otitis media – Pharyngitis and tonsillitis – Acute bronchitis and acute exacerbations of chronic bronchitis – Uncomplicated gonorrhea (cervical/urethral).
Side Effects
Diarrhea (if severe diarrhea occurs, cefixime should be discontinued), changes in the color of stool, nausea, abdominal pain, dyspepsia, vomiting, Headache, dizziness, seizures , Transient rises in liver transaminases, alkaline phosphatase and jaundice , elevation of serum amylase.
Precaution
Cephalosporins should be given with caution to penicillin sensitive patients, as there is some evidence of partial cross-allergenicity between the penicillin’s and cephalosporins.
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